Animal replica reports have not been executed Together with the drug combination-promethazine and codeine. It is far from acknowledged regardless of whether this drug mix can result in fetal hurt when administered into a Expecting woman or can affect replica ability.

It is important that Promethazine HCl Oral Alternative is measured with the precise measuring machine (see Safety measures-Information for Clients). A home teaspoon isn't an precise measuring system and could lead to overdosage, specially when 50 % a teaspoon is always to be measured.

Usually do not choose any benzodiazepines or medicines that can result in drowsiness or sleepiness through therapy with Promethazine Hydrochloride and Codeine Phosphate Oral Option. Ask your Health care supplier for an index of these medicines if You're not sure.

Postmarketing cases of respiratory despair, which includes fatalities, are documented with usage of Promethazine in pediatric individuals fewer than 2 a long time of age. A variety of weight-primarily based doses of Promethazine have resulted in respiratory melancholy in these people.

Stimulation might be evident, especially in small children and geriatric individuals. Convulsions may well rarely take place. A paradoxical-sort reaction has been reported in little ones receiving single doses of 75 mg to a hundred twenty five mg orally, characterised by hyperexcitability and nightmares.

Antihistamines are contraindicated for use from the remedy of lower respiratory tract signs or symptoms like bronchial asthma.

Anticholinergics - Concomitant utilization of other brokers with anticholinergic Attributes should be undertaken with caution.

Promethazine HCl Oral Alternative could impair the psychological and/or Actual physical skills essential for the functionality of probably harmful tasks, including driving a auto or operating machinery. The impairment could be amplified by concomitant utilization of other central-anxious-process depressants such as alcohol, sedatives/hypnotics (which includes barbiturates), narcotics, narcotic analgesics, standard anesthetics, tricyclic antidepressants, and tranquilizers; thus such agents must both be eradicated or presented in decreased dosage inside the presence of promethazine HCl (see PRECAUTIONS – Info for Sufferers and Drug Interactions).

Labor or Delivery Opioids cross the placenta and will develop respiratory despair and psycho-physiologic effects in neonates. An opioid antagonist, including naloxone, need to be available for reversal of opioid-induced respiratory depression inside the neonate.

Anaphylactic reactions, as adjunctive therapy to epinephrine and various regular measures, once the acute manifestations are actually controlled.

This will occur Even when you just take Promethazine Hydrochloride and Codeine Phosphate Oral Answer accurately as prescribed by your healthcare service provider. Your chance of addiction, abuse, and misuse is greater should you or a loved one has a heritage of drug or Alcoholic beverages abuse or habit, or psychological health problems.

The opioid antagonists, naloxone and nalmefene, are certain antidotes for respiratory depression ensuing from opioid overdose. For clinically sizeable respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist shouldn't be administered inside the absence of clinically substantial respiratory despair. As the length of opioid reversal is expected to generally be a lot less than the length of motion of codeine in Promethazine HCl and Codeine Phosphate Oral Option, meticulously check the patient right until spontaneous respiration is reliably reestablished.

Sedation This item relieves apprehension and induces a peaceful rest from which the affected individual may be easily aroused.

Promethazine HCl may very well be made use of by itself or being an adjunct to narcotic analgesics through labor (see check here DOSAGE AND ADMINISTRATION). Minimal facts advise that utilization of Promethazine in the course of labor and shipping and delivery does not have an considerable effect on the duration of labor or supply and would not improve the chance of want for intervention within the new child.